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Quick Answer: Zepbound causes nausea and sickness in 24-30% of patients primarily by slowing gastric emptying, which delays food movement from the stomach and triggers gastrointestinal discomfort

doi: 10.1155/2019/8905917

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For example, metformin primarily reduces liver glucose production, while semaglutide is a GLP-1 receptor agonist that stimulates insulin release

Quick take: retatrutide combines appetite control (GLP-1), metabolic support and potential anti-nausea synergy (GIP), and a mild increase in energy expenditure (glucagon)

doi: 10.4162/nrp.2017.11.2.97 19 CraigD