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It may take a few weeks to notice visible changes, and mild side effects are possible during the adjustment phase

For agents with a long elimination half-life (6, 7), typically used at more than 10 times higher than physiological concentrations, such periods probably would need to be much longer than a week

January 2012

However, some healthcare professionals may prescribe this medicine off-label for certain medical conditions in patients 18 years or younger

The sublingual route works best for lipophilic compoundsmolecules that can passively diffuse through the lipid bilayer of mucosal cells rather than requiring active transport

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