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The main concerns are quality control and lack of long-term human data

Second, several experiments whether they involve slices of brain tissue, animals, and even human volunteers have strongly suggested that GLP-1 drugs specifically act on our dopamine cycles and affect neural activity in the hypothalamus, the appetite-controlling region of the brain

Wu J, Zhang Y, Liu T, et al

(PubMed mirror for the open-access abstract.) Lake JE et al