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The transient elevation of peripheral cytokines, such as IL-6 induces sustained effects through the following mechanisms: 1) Activated microglia can sustain a pro-inflammatory phenotype over extended periods, thereby potentially becoming a continuous source of IL-1 and TNF- within the central nervous system (127, 128)

BMC Cancer 13:601 Zhdanov AV, Waters AH, Golubeva AV, Dmitriev RI, Papkovsky DB (2014) Availability of the key metabolic substrates dictates the respiratory response of cancer cells to the mitochondrial uncoupling

Hormone replacement therapy improves arterial stiffness in normotensive postmenopausal women

The images were analysed by ZEN pro software (Carle Zeiss, German), ImageJ and Photoshop CS6 (Adobe)

After the age of 60, the GSH status deteriorates even more drastically

This would be expected to have an effect on the rates amino-acid-requiring processes of one-carbon metabolism and glutathione synthesis