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Amgen's MariTide, which combines GLP-1 agonism with GIP antagonism, was specifically designed based on genetic evidence suggesting this combination could reduce nausea while maintaining weight loss efficacy [44]

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Concurrent degeneration and/or single cell necrosis is possible

In clinical trial settings, Phase II studies (referenced via DOI 10.1210/jcem.83.2.4551) have examined MK-677 in the context of GH deficiency and muscle-wasting conditions, with particular interest in its IGF-1 normalizing effects in older populations

Patents were also extracted using the name of the applicant companies