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Mechanistically, the antibody not only neutralized extracellular HMGB1 to mitigate its cytotoxic effects on cerebrovascular endothelial cells but also inhibited subsequent neuroinflammatory responses [348]

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Studies demonstrated that berberine contributed to AMPK signaling pathway activation and participate in anti-neuroinflammation

N-terminal hexanoyl and C-terminal modifications create more stable, lipophilic molecule

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