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Underlining these concerns, a new paper documents the experiences of three women who had all been taking high doses of a GLP-1 receptor agonist called tirzepatide before running into problems

Ozempic is injected once a week, rather than daily, like Saxenda

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The main difference between the mechanisms of action of the two drugs is that liraglutide only acts on the GLP-1 receptor, while tirzepatide is a co-agonist of GIPR next to the GLP-1R with a greater affinity to the GIPR [39]

Interaction risk: Since DSIP may affect GABA and NMDA receptor activity, combining it with other sleep medications, alcohol, or sedatives could increase the risk of excessive drowsiness or neurological side effects

Then five to 10 years later, we started seeing vascular and cardiac issues