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An 8-week randomized controlled trial found that 2000 mg of American ginseng improved cancer-related fatigue in 364 cancer patients

They suggested that the absence of methoxyl group in bisdemethoxycurcumin, coupled with the presence of two and one methoxyl groups in curcumin and demethoxycurcumin, respectively, must have played a role in determining the outcome of this study

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Some studies also investigate DSIP indirectly in pain and chronic pain models, primarily by evaluating how sleep quality and stress modulation affect pain perception rather than through direct analgesic effects