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Silymarin is also protective against several classes of nephrotoxic drugs, in particular cisplatin and doxorubicin

Cui Y, Cai T, Zhou Z, Mu Y, Lu Y, Gao Z et al (2020) Health effects of alternate-day fasting in adults: a systematic review and meta-analysis

Because of that, plants developed complexed ROS control system based on enzymes (like glutathione reductase-GR, glutathione S-transferase-GST, glutathione peroxidase-GPX) and scavenging non-enzymatic hydrophilic molecules like ascorbate (AsA) and glutathione (GSH) (Noctor and Foyer, 1998)

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In cancer cells, GPER activation influences the ERK1/2 pathway, promoting the degradation of proliferation-associated proteins [86, 87] and suppressing tumor cell apoptosis

Front Cell Dev Biol (2022) 10:956274