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Hind limb blood flow measurement with laser speckle imaging To assess endothelium-dependent vasodilation in the quadriceps muscle, five animals per group (WT and VECAD IGF- 1R KD) were anesthetized using isoflurane (induction 34%, maintenance 1.52%) in oxygen and mechanically ventilated to ensure stable respiration

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Increase in Low-Density Lipoprotein Cholesterol In the pool of 13 placebo-controlled trials of glycemic control, changes from baseline in mean lipid values were reported in FARXIGA-treated adult patients compared to placebo-treated patients