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Two main classes exist: GHRH analogs (CJC-1295, Tesamorelin): These mimic growth hormone-releasing hormone, activate GHRH receptors on pituitary, and stimulate GH synthesis and release

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Self-reported community sources commonly describe starting at very low doses (10-25% of the typical maintenance dose) and slowly titrating upward to reduce this

Initial weight loss often appears within 2 to 4 weeks

Prescription GLP-1 medications such as semaglutide are typically prescribed under the guidance of a healthcare provider who can evaluate whether the treatment is appropriate

Nussbaum RL, Ellis CE