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Trials of orforglipron and lower-dose tirzepatide suggest that if and when these drugs are licensed, they could be used to maintain weight loss after higher-dose injectable incretin therapies 45

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Mice with GH resistance and profoundly reduced IGF-I levels appear to be healthy and to exhibit increased life expectancy, along with reduced fasting glucose and circulating insulin concentrations (34)

It is particularly common when treatment begins or when the dosage is increased

However, this therapy is not suitable for everyone

This can translate into increased vulnerability to oxidative stress, slower regeneration, persistent fatigue and a reduced detoxification capacity