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GLP-1RAs and other incretin-based NuSHs, by ameliorating hepatic lipotoxicity, improving insulin sensitivity, and reducing inflammation, may help restore a more functional immune milieu

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Importantly, GLP-1 receptor agonists are not indicated for type 1 diabetes or diabetic ketoacidosis

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1 2 These support biological plausibility but do not meet the standard of clinical proof

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