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Pregnancy and breastfeeding are also named as contraindications

It was found that 48-h exposure to rotenone significantly increased Ca 2+ content, indicated by Fluo3(i) fluorescence, and increased ceramide content, decreased cell size measured as FSC, and increased annexin V binding

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Further, the appetite-suppressing effects of CCK are blocked with ablation of right vagal afferents, neurons in the lPBN and substantia nigra, and antagonism of D1R/D2Rs in the dorsal striatum [106], suggesting overlapping central mechanisms of CCK with RYGB