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Mineralocorticoid receptor in smooth muscle contributes to pressure overload-induced heart failure

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JANUMET is not recommended in patients with an eGFR between 30 and less than 45 mL/min/1.73 m2 because these patients require a lower dosage of sitagliptin than what is available in the fixed combination JANUMET product

Eating smaller, balanced meals and avoiding prolonged fasting can stabilize blood sugar and reduce headache frequency for some patients

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This development has led to the introduction of several GLP-1 receptor agonists and DPP-4 inhibitors on the market [3], which are featured prominently in current recommendations because of their effectiveness, safety and proven cardiovascular benefits [33]