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Sarika Arora, MD Lets be honest
The AOP was developed based on OECD's guide no
Supports healthy liver function
However, long-term risks such as rare adverse effects, metabolic effects over years, effects on bone, gallbladder, and pancreas need phase-3 trials and post-marketing surveillance to ensure the medication is safe for long-term use
Mann JFE, Rossing P, Bakris G, et al