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GCs are crucial for supporting and maintaining follicle growth, and their physiological condition greatly influences the fate of the follicle (Yuan et al., 2019)

In animal studies, this drug not only directly activates GLP-1 receptors in the hypothalamus and brainstem but also indirectly modulates neuronal circuits in other regions involved in eating behavior, such as the lateral parabrachial nucleus

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Additionally, in a standardized meal test, MC4R variant carriers were reported to exhibit suppressed hunger, enhanced satiety, and a 28% reduction in energy intake during an ad libitum feeding test, with no significant differences compared to the control group