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6b, the kidney exhibited the highest normalized dosage distribution of Cu 5.4 O USNPs (4.4 %ID g 1 ), while the distributions of NPs in the heart, liver, spleen, and lung reached 0.89, 3.2, 2.1, and 0.94 %ID g 1 , respectively

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Furthermore, depletion of HIF-1 caused a reduction in mRNA expression of glycolytic genes investigated, although only Pgam2 was statistically significant (Fig