Further analysis revealed that male L-DKO livers had dramatically increased markers of apoptosis and oxidative DNA damage compared to female mice (Fig
To test if this mechanism was at play upon depleting GSH in the liver, we treated Gclc L-KO mice with T0901317, an LXR agonist
To view a copy of this licence, visit About this article Cite this article Goldberg, L., Haas, E.R., Wu, J
It is a very important antioxidant, participates in detoxification of certain drugs, toxic environmental chemicals, protects against lipid peroxidation and electrophiles, has antiviral effects, is involved in the biosynthesis of DNA, proteins, and leukotrienes, cell proliferation, apoptosis, neurotransmission, and neuromodulation
Lipid Metabolism and Triglyceride Reduction Glutathione aids liver lipid metabolism by lowering triglycerides and non-esterified fatty acids (NEFA), both associated with liver stress and inflammation
Immunofluorescence assay The immunofluorescence method referred to our previous study 49
