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Indeed, GABAergic or benzodiazepine receptor-mediated mechanisms inhibit CRF release [50], and anxiolytic benzodiazepines can reverse or antagonize in experimental animals several CRF-mediated behavioral effects that are thought to be related to stress [51, 52]

RAW 264.7 cells were activated with proinflammatory stimuli to induce increased intracellular ROS levels, followed by incubation with various formulations

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This method is less precise because it does not deposit the medication near the target nerve root, and the steroid solution is free to spread within the epidural space

3.2.2 Passive Diffusion Across Cell Membranes Due to the significant improvement in lipophilicity, SAG can cross cell membranes via passive diffusion