Patients planning elective surgery need to tell their surgeons if theyre on a GLP-1 medication
After reviewing clinical trial data, post-marketing surveillance reports, and real-world evidence across millions of prescriptions, the EMA concluded in 2024 that the available evidence does not support a causal association between GLP1 receptor agonists and suicidal or self-injurious behavior
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10.1056/nejmoa2032183
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However, when the integrity of the intestinal barrier is damaged, the submucosal immune cells are exposed to bacteria, dietary antigens and autoantigens, which can result in adverse immune activation or tolerance response failure, leading to autoimmune diseases [79]