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Another achievement of this study was the fact that we successfully established a BBB in vitro model, a tight endothelial barrier using hydrocortisone-treated b.End3 cells, to evaluate nanoformulations (Fig
Ursodeoxycholic acid and other bile acids with a pKa which is sufficiently high that it enables them to exist within bile in their non-ionized (protonated) state, may be reabsorbed across the biliary epithelium by non-ionic diffusion
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Furthermore, the pathophysiology of PD involves numerous signaling pathways, including inflammatory signaling pathways like NF-B and NLRP3 inflammasome
Another application of DSIP could be the treatment of narcolepsy
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