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Wegovy currently carries a boxed warning (the most serious designation from the FDA) for pancreatitis, kidney injury, gallbladder disease, and depression/suicidal ideation, and for risks of thyroid tumors, based on animal studies

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Brain-Derived Neurotrophic Factor BDNF Supports neurological function, cognitive performance and healthy brain activity

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This large cohort of lower financial return programmes demands scrutiny to confirm that each serves a high unmet need and is differentiated or first in class, justifying its place in an increasingly resource-constrained portfolio