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"They're treating it like you can now come purchase a smartphone." Novo's once-daily Wegovy pill was recently approved in the U.S

I would frame these findings as hypothesis-generating and clinically important, but not definitive proof that GLP-1 therapy directly caused the reductions we observed, Sheer says

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to estimate insulin sensitivity in patients treated with placebo, TZP or semaglutide after 28 weeks of treatment, achieving a hyperinsulinemic, euglycemic clamp experiment, followed by a hyperglycemic clamp (216 mg/dL) to estimate insulin secretory responses

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Acknowledgements We thank Angelika Pllniemi for technical assistance, Matthew Maasdorp for proofreading the manuscript, Tilman Tietz for commenting on the manuscript and helping with the experimental crosses and Eric Dufour for commenting on the manuscript