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Komada M, Takao K, Miyakawa T

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The MC1R gene encodes one melanocortin receptor best known for its role in skin and hair pigmentation, including tanning response and hair color

Central to this process is the Nuclear Factor Erythroid 2Related Factor 2 (Nrf2)-ARE signaling pathway, which significantly enhances the activity of key antioxidant enzymes

Pravastatin Treatment and Antioxidants Supplementation Thirty-day-old male LDLr -/- mice received pravastatin (Medley Ltda, Brazil) diluted in the drinking water (400 mg/L) during 3 months as previously described (Lorza-Gil et al., 2016)