Opin Microbiol 2020, 55, 1725
The antibiotic resistance crisis
Wu, Yan
This may be relevant with low dietary creatine, vegetarian or vegan diets, rapid growth, high muscle demand, athletic activity or increased brain-energy needs
The optimal scheme of organically combining lactate metabolic regulation with other therapies, which includes screening the most effective lactate regulation target, determining the best treatment time window, and identifying the most appropriate action site to maximize antitumor efficacy, remains to be further explored
At the same time, elevated tumor GSH can be exploited as a conditional trigger for prodrug activation, nanomedicine-based delivery, or metal-driven cytotoxicity, thereby converting a classical resistance factor into a therapeutically actionable vulnerability