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Any medication has what we call a therapeutic window, so if you take too much aspirin, its going to cause a gastric ulcer or bleeding, and so on

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For repeat-dose studies, variability in quantitative endpoints approached 0.5 log units

Have severe or unstable medical conditions (e.g., uncontrolled diabetes, advanced kidney or liver disease) without close medical supervision

Getting enough quality zs is important for regulating hunger and metabolism