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Radiation injuries to other organs and tissues, such as the urinary system, where acute nephritis and acute cystitis can occur, are also common, and in the late stages, bladder atrophy may develop (100, 101)

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Moreover, melatonin has been shown to reduce ferroptosis in various diseases affecting multiple organs, suggesting its potential as a therapeutic agent for ferroptosis-associated conditions [38, 39]

TP53 -mutated samples were excluded