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Side effects include fever, low blood pressure and irregular heart rhythms

54 However, these studies were observational or post hoc analyses, and dementia was not the primary outcome

The driver is rapid weight loss and physiologic change

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By preferentially promoting cAMP-mediated intracellular pathways, thought to be central to insulin secretion and appetite regulation, this receptor bias may enhance metabolic efficacy while potentially reducing the activation of alternative signalling cascades associated with receptor desensitisation or adverse effects (although the clinical relevance of this remains to be fully established)