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Weak opioid drugs include codeine, dihydrocodeine (DHC), and tramadol

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Keratinocyte differentiation markers including keratin 1, keratin 10, and involucrin demonstrate appropriate expression patterns, indicating that GHK-Cu promotes not merely rapid re-epithelialization but proper structural and functional restoration of the epidermal barrier

Elastin fibers are damaged and have limited capacity to regenerate naturally (adult humans produce very little new elastin after puberty under normal conditions)

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