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Lessons learned from other preliminary or unsuccessful interventions are also considered in ESM Appendix 3, including modulators of miRNAs, selective peroxisome proliferator-activated receptor modulators, hydroxysteroid dehydrogenase-1 inhibitors, adenosine monophosphate-activated protein kinase activators, direct modulators of glucose metabolism, regulators of diacylglycerol acyltransferase, sirtuins, selective androgen receptor modulators and agents to modify the microbiome

And how do they intersect with broader cultural movements, such as fat positivity and digital health optimization (i.e

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GLP-1 (glucagon-like peptide-1) is a hormone naturally produced in the gut that regulates appetite and blood sugar