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International Journal of Environmental Research and Public Health, 20 (6), 4686

Unfortunately, even when a persons diet is rich in B12 or if they take a daily supplement, they may still be lacking, as vitamin B12 can be difficult to absorb orally

Long-term side effects of NAD treatment have not been described

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These challenges have historically restricted the development of orally administered agents in this class, but ongoing pharmaceutical research continues to investigate the feasibility of various enhancement technologies