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The catalytic cycle of GPX4 involves dynamic selenocysteine redox transitions
Within the mitochondria, GSH concentrations are similar to those in the cytoplasm and range from 5 to 11 m M (103, 120, 330)
After full-text assessment, we excluded studies on diabetes mellitus ( n = 154), studies on Parkinson or neurodegenerative conditions ( n = 8), and in vitro, animal and human studies that did not investigate pain as primary and/or secondary outcome ( n = 130)
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Retrospective case series suggest: Significant weight loss Improved glucose time-in-range Reduced insulin needs Early results are encouraging, but prospective trials are still ongoing