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If you're postpartum, on certain medications, pregnant or breastfeeding - retinoids are generally contraindicated

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Front Immunol 11:209 Knipfer L, Schulz-Kuhnt A, Kindermann M, Greif V, Symowski C, Voehringer D, Neurath MF, Atreya I, Wirtz S (2019) A CCL1/CCR8-dependent feed-forward mechanism drives ILC2 functions in type 2-mediated inflammation

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"Probiotic supplementation and trimethylamineNoxide production following a highfat diet." Obesity 23.12 (2015): 2357-2363