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Extreme cold can damage the peptide structure just as effectively as heatif your semaglutide accidentally freezes, do not use it, as the molecular arrangement may be permanently altered

doi: 10.1016/j.intimp.2025.114141 240 ChenJWShanTKWeiTWJiangQQDuCGuLFet al

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While the change is not dangerous, it can be distressing for those who feel like their outer appearance no longer reflects their inner vitality

Thats not enormous, but if youre already close to your daily ceiling, it matters

After removing duplicates and screening titles and abstracts, 170 studies were assessed for full-text eligibility