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Compression-induced invasion and migration of breast cancer cells are attributed to the activation of the MIC Piezo 1 [121] and the formation of leader cells, which possess filopodia at their leading-edge, thereby driving persistent and directional motility [120]

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The cells were treated with these cocktails for 3 days, with variations in CHIR concentration and the presence of Ly or PD to optimize DE induction efficiency [1]