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Low-carb dietary approaches may be particularly helpful during the transition for people who notice significant blood sugar instability
Contrast to peptides, small-molecule GLP-1 agonists like orforglipron are synthesized via conventional chemical routes in organic solvents, which can be scaled more like typical pharmaceuticals (crystallization, distillation, continuous reactors)
Most plan sponsors cover these medications only for FDA labeled/clinical compendia-supported conditions
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As GLP-1s gain approvals for additional disease areas - Novo is studying semaglutide in addiction, osteoarthritis, and MASHthe companies continue extending patent protection through method-of-use claims that could sustain market exclusivity well beyond initial compound patents [40]
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