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The combined neuroprotective, synaptogenic, and neurogenic mechanisms proposed for these compounds encourage the possibility that they may be a treatment option for neurodegenerative and neuro-traumatic disorders beyond AD

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Such universal homeostatic brakes on runaway dynamics allow learning networks to benefit from a broad variety of plasticity rules, STDP windows, and activity patterns while, at the same time, robustly maintaining stable regime of operation and keeping excitatory synapses in operating range allowing for new learning (Chistiakova et al., 2015, 2019)

J Cogn Enhanc 3:193206 Rivera MC, Mastronardi C, Silva-Aldana CT et al (2019) Myalgic encephalomyelitis/chronic fatigue syndrome: a comprehensive review