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Additionally, GLP-1 receptors are expressed in parts of the brain involved in mood and the reward system, which could explain the reductions we observed in alcohol and substance use. These benefits appeared especially pronounced in psoriasis patients compared with matched controls, suggesting a possible synergy between systemic inflammation in psoriasis and the mechanisms of GLP-1 RAs

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rather, the nausea and gastrointestinal symptoms that accompany initial receptor activation gradually diminish as the nervous system recalibrates