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In a randomized, placebo-controlled study of 495 patients with intermittent claudication, 2 g/day of propionyl-L-carnitine for 12 months significantly increased maximal walking distance and the distance walked prior to the onset of claudication in patients whose initial maximal walking distance was less than 250 meters (m), but no effect was seen in patients who had an initial maximal walking distance greater than 250 m (65)
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Statistical Analyses Data were analyzed using GraphPad prism for windows (version 5, Graphpad Software, San Diego, CA, USA)
Several studies suggest that this approach can be an effective method for achieving modest but clinically meaningful weight loss
Regular monitoring, lab testing, and periodic reassessment are essential to reduce potential harm and identify early warning signs