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J Intern Med

Apart from inducing oxidative stress, ROS molecules attack almost every component of the cell and cause further nonspecific damage to surrounding tissues

Its effect is more targeted and incremental

Beta-blockers, especially when delivered as part of guideline-directed medical therapy, decrease the risk of major cardiovascular events, reduce mortality and hospitalization in patients with HFrEF, lessen the symptoms of heart failure, improve the clinical status of these patients, and reduce future clinical deterioration associated with heart failure

New York: Simon & Schuster

When tracking trends, use comparable preparation conditions and preferably the same laboratory method