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Its molecular core involves the receptor interacting serine/threonine kinase 1 (RIPK1)-receptor interacting serine/threonine kinase 3 (RIPK3)-mixed lineage kinase domain like pseudokinase (MLKL) signaling axis (119)

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Under mechanical stress, both cardiomyocytes and cardiac fibroblasts secrete various inflammatory mediators, including interleukin-6 (IL-6), IL-1, tumor necrosis factor (TNF-), and nucleotide-binding and oligomerization domain (NOD)-like receptor thermal protein domain-associated protein 3 (NLRP3)[72, 73] (Figure 1)

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