Small molecule programs remain high risk high reward Pfizers pullback from its own oral GLP-1 programs has highlighted a major scientific challenge: biased agonism can improve GI tolerability but does not eliminate hepatotoxicity risk
Side effects are a manageable part of GLP-1 treatment, not a reason to avoid it or stop it prematurely
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Weight loss injections are contraindicated in pregnancy, and manufacturers recommend specific discontinuation timeframes before attempting conception: approximately two months for semaglutide, one month for tirzepatide, and a shorter period for liraglutide, as detailed in their respective Summary of Product Characteristics