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Methionine primarily protects against oxidative stress (Table 2) (through its conversion to S-adenosylmethionine) and acts as a structural substitute for hydrocarbon residues in proteins [46, 47]

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This hypoxic environment was maintained using a gas mixture (1% O 2 , 5% CO 2 , and 94% N 2 )

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Serum Cu also drives the oxidation of LDL to form copper-ox-LDL, a key ligand that binds to the LOX-1 receptor on ECs to initiate plaque formation [189]