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Review Article Abstract Introduction Retatrutide for Treatment of Obesity Retatrutide for Treatment of Type 2 Diabetes Effects of Retatrutide on Cardiovascular Risk Factors Safety of Retatrutide Effect of Retatrutide on Heart Rate Advantages of Retatrutide Limitations of Retatrutide Conclusions and Current Needs References Safety of Retatrutide In the 2 phase 2 trials, 16-17% discontinued retatrutide compared with 0-4% with placebo due to adverse effects (Table 1) [3,4]
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Nat Commun 16 , 6445 (2025)
Rouault, A
A diferencia de la semaglutida (mono-agonista GLP-1) y la tirzepatida (dual GLP-1/GIP), Retatrutida aade la rama del glucagn, lo que en modelos preclnicos incrementa el gasto energtico basal adems de reducir el apetito y mejorar la sensibilidad a insulina
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