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The FDA's adverse event reporting system depends on voluntary paperwork

Most clinical guidelines now frame GLP-1 agonist treatment as indefinite rather than time-limited, similar to treating hypertension or diabetes

Drug companies have brought several to market as medications, including mainstay GLP-1 treatments for diabetes and weight loss

For example, individuals in the cohorts were older and mostly white men, thus hurting the results generalizability to the general population, while the researchers could not rule out residual confounding

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Some users experience temporary headaches or fatigue