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These data together with those obtained for 2-VP [14,15] let us to select NEM as the most suitable alkylating agent to protect the oxidation of thiol groups, according to what suggested previously [Butler, Tietze]

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When glutathione levels drop, cells lose their defense, making them more prone to damage and cancer

Metformin is generally weight-neutral or causes slight weight loss

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Oxidative stress damages cells