What has become increasingly clear is that GLP-1 receptors are expressed throughout the bodyin the brain, heart, endothelium, pancreas, and immune cellsmaking this pathway a powerful modulator of systemic aging processes
Mol Endocrinol 16(5):10291039
However, individuals with a medical or family history of thyroid cancer or those with multiple endocrine neoplasia syndrome type 2 (MEN2) should exercise caution, as GLP-1 is not recommended for this demographic
Medicare typically covers semaglutide only for type 2 diabetes
Larger volumes can be slightly more challenging for sublingual administration because there is more liquid to hold in a relatively small space
They are also known to reduce thirst, further diminishing saliva production