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In a 52 week Phase 2 trial, overweight/obese individuals without diabetes lost 13.7% of their body weight (placebo subtracted) after receiving maridebart cafraglutide (420 mg once monthly), and overweight/obese individuals with diabetes lost 10.6% of their body weight and saw a decrease in HbA 1c of ~17 mmol/mol (1.5%, placebo subtracted) after receiving maridebart cafraglutide at the same dose (Table 2) [55]

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These substitutions can affect drug stability, absorption, and may trigger allergic reactions or other adverse effects

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Among those who had bariatric surgery, that risk declined by 22% over 10 years compared to those who received no treatment