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Moreover, TB-500 also appeared to have promoted the expression of CD31, -smooth muscle actin (-SMA), Ang2, tie2, VEGFA, N1ICD, and p-p65 in the muscle tissues of murine CLI models

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The most common side effects are described below : Gastrointestinal Issues: Both medications can cause gastrointestinal side effects such as nausea, vomiting, diarrhea, and constipation, especially when starting the treatment or during the dose titration